What is Synedica Retatrutide 40mg?
Synedica Retatrutide is a research-grade retatrutide formulation supplied in a pre-filled pen device. Each pen contains 40mg of retatrutide ā a triple receptor agonist targeting GLP-1, GIP and Glucagon receptors simultaneously. This triple mechanism is what distinguishes retatrutide from semaglutide (GLP-1 only) and tirzepatide (GLP-1 + GIP only).
Phase 2 clinical data published in the New England Journal of Medicine demonstrated an average 24.2% body weight reduction at 48 weeks ā the highest figure recorded for any compound in this class to date.
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Research Background
Retatrutide (LY3437943) is currently in Phase 3 TRIUMPH clinical trials. The unique glucagon receptor component increases resting energy expenditure ā a mechanism not found in semaglutide or tirzepatide ā making retatrutide the most potent compound in this class for research purposes.




